Factors Which Can Affect IVF Success Outcomes

Factors Which Can Affect IVF Success Outcomes:

IVF, standing for in vitro (glass) fertilization, is the term given for adding the man’s sperm to the woman’s egg in a laboratory setting, rather than through natural process. Often couples who cannot conceive choose this path when they still wish to have children, which may be due to quality or quantity of sperm, or tube blocking or cervical issues in the woman. IVF success rates can depend on many factors.

Age is a prominent factor in the success rates, and the general attitude is that the younger a woman is, the more likely it is she will be able to succeed with IVF. Women aged under 35 had around a 33% of success, and women over 44 had around a 5% chance, though these statistics are not accurate. Progressive technology advances suggest an increase in success each year.

IVF success can be affected by the physician administering the treatment, and the clinic they operate in. Large centers are more successful than smaller ones, and the difference between doctors in the same clinic can be as much as 32%. This could be a reflection on the ability of the physician, but it could also be that some physicians attract older women with less chance of success.

Cancellation of the process is also factored in, as around 12% of IVF cycles are cancelled before the egg is collected. The most common causes for this are poor (or no) egg production (83%), or the patient having personal reasons to discontinue (10%). This is more likely as patient age increases, suggesting age correlates with lessened egg production. For women under 35 this is estimated at around 9%, whilst women over 40 are at around 42%.

It is likely that the couple has a problem with fertility when they seek IVF, and in some cases both the man and woman have issues. Donor sperm and eggs are available and can be more effective with a higher success rate than those using their own sperm and eggs. For donor eggs there is around a 40% overall delivery rate per transfer, against 30% non-donor. Transfer is the term used for replacing an embryo.

A higher transfer number can induce a higher chance of getting pregnant. However, more transfers increases both the likelihood as well as the chance of multiple pregnancies. One transfer has a low rate of both, whereas three transfers is much higher. In the UK women under 40 are restricted to a maximum of two transfers, however some evidence suggests two is just as effective as three, and less likely to induce multiple pregnancies.

Couples who have been infertile for longer are less likely to have a live birth baby. Those who have been infertile only recently have around a 20% chance of success, whilst those lasting over 12 years drop to around 11%. Factors to this seem to vary in significance, where the influence of the male is less than the influence of endometriosis or tubular issues.

Women who have been pregnant before are more likely to have a live birth, and those who have had successful IVF before have an even higher chance. Lifestyle, such as being overweight, can reduce the chance of successful treatment, and behavior such as smoking can reduce the chance of pregnancy. It is also possible that race has an influence on IVF success rates, based on fat distribution and vulnerability to disease.

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Factors Which Can Affect IVF Success Outcomes By house | August 27, 2011

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